Abstract: Objective To investigate the clinical features of patients with primary liver cancer （PLC），and the current states of clinical diagnosis and multi-disciplinary team（MDT） management in clinical practice. Methods The clinical data of 5390 patients with PLC enrolled in our general hospital in south China from 1st Jan， 2010 to 30th Dec，2013 were retrieved，and we reviewed the patient's gender，age，etiology，qualitative detection of serum HBeAg，HBV DNA and alpha fetoprotein（AFP） levels，Child-Pugh class，Barcelona clinic liver cancer （BCLC） stages and the strategy of treatment for them. Results The median age of 5390 patients was 53-year-old，while male persons accounted for 87.4% and the prevalence of hepatitis B virus （HBV） infection was 84.15%；serum AFP positive（≥20 μg/L） accounted for 65.63%，and in HBeAg positive patients was 76.95% （671/872），much higher than that in HBeAg negative patients [54.11%（685/1266），P<0.01]；serum HBV DNA positive （≥1.0×103IU/ml） was 70.73 %（1022/1445）；as for pathological classification，the hepatocellular carcinoma （HCC） ranked first （84.7%）；the patients with BCLC stage C was 41.0% and B 31.0%；only 10% of PLC patients received comprehensive treatment；There were 56（5.3%） out of 1051 patients at initial admission，and 28 （2.7%） at repeated admission receiving MDT therapy；the hospitalization fee for conventional management was 28 thousand RMB，which was reduced by 6.83% to 26 thousand for MDT treatment. Conclusion The patients with PLC are often with underlying chronic HBV infection and are likely to be in advanced stage when hospitalized. The MDT should be recommended for their diagnosis and treatment.

Key words: Primary liver cancer, Barcelona clinic liver stage, Multi-disciplinary team, Fetoprotein