Abstract: Objective This study was aimed to investigate the possible clinical factors contributing to the development of radiation-induced liver disease（RILD） in patients with hepatocellular carcinoma receiving three-dimensional conformal radiotherapy. Methods Between March 2009 and December 2015,we included 39 patients with hepatocellular carcinoma who received three-dimensional conformal radiotherapy. Clinical data,including gender,age,other treatments,liver function test Results,and three-dimensional conformal radiotherapy parameters were retrieved for analysis. Multivariate non-conditional Logistic regression analysis was used to identify the predictors of RILD. Results Out of 39 patients with hepatocellular carcinoma,fourteen（35.9%） developed RILD after three-dimensional conformal radiotherapy;The unconditional multivariate Logistic analysis showed that the pretreatment Child-Turcotte-Pugh score ≥6 [odds ratio （OR）:24.95,P=0.005] and age ≥60 years （OR:15.72,P= 0.020） were independent risk factors for the development of RILD. Conclusion The occurrence of RILD must be taken into consideration when the three-dimensional conformal radiotherapy is applied to the patients with hepatocellular carcinoma,and the primary identification of the risk factors for RILD is important.

Key words: Hepatocellular carcinoma, Three-dimensional conformal radiotherapy, Radiation-induced liver disease, Logistic analysis