Abstract: Objective To observe the clinical efficacy of combined treatment of cerebrolysin and probiotics for patients with hepatic encephalopathy（HE）. Methods 76 patients with HE were randomly divided into combined treatment group and control group,with 38 cases in each. The patients in control group were treated with probiotics for 4 weeks,and the patients in combined treatment group were treated with cerebrolysin and probiotics for 4 weeks. The scores of number connection test （NCT） and digit symbol test （DST） were applied to evaluate brain functions.The blood ammonia,ALT,tumor necrosis factor-α （TNF-α） and serum bilirubin levels were assessed before and after the treatment. Results At the end of 4 week treatment,the scores of NCT and DST in control group were （70.47±8.15） and （31.52±8.32）,while they were （41.06±6.61） and （56.89±9.23） respectively in combined treatment group,significantly different in the two groups（P<0.05）;The levels of blood ammonia,ALT,TNF-α and TBIL in control group were（69.71±19.56） μmol/L,（66.34±15.82） U/L,（346.75±45.63） pg/ml,and（51.32±8.77） μmol/L,while they were（49.65±18.33） μmol/L,（58.48±12.66） U/L,（142.57±39.51） pg/ml and（40.19±8.24） μmol/L in combined treatment group,with statistically significant difference（P<0.05）. Conclusion The clinical efficacy of cerebrolysin combined with probiotics for treatment of patients with HE is good,and it is worth to prove in clinical practice.

Key words: Hepatic encephalopathy, Cerebrolysin, Probiotics, Efficacy