Abstract: Objective The aim of this study was to summarize clinical feature and antibiotic application in a series of patients with bacterial liver abscess (BLA). Methods A total of consecutive 90 patients with BLA were encountered in our hospital between May 2020 and May 2025, and all underwent puncture drainage and intravenous antibiotic administration. Bacteria separation, characterization and drug sensitivity tests were routinely performed. Results Male to female ratio in our series was 2.1:1, with mean age range of 60.5±7.4 yr; underlying diabetes accounted for 45.5%, cholelithiasis for 35.6%, hypertension for 32.2%, malignant tumors for 5.6%; white blood cell count was (12.0±1.3)×10⁹/L, serum C-reactive protein level was (69.4±5.1)mg/L, serum procalcitonin level was (2.4±0.2)ng/mL, and serum albumin level was(31.5±9.6)g/L; single abscess accounted for 74.4% and multiple for 25.6%; abscess at right lobe accounted for 77.8%, at left for 11.1% and both for 11.1%; diameter of abscess was (6.8±1.1)cm; prevalence of positive bacteria was 80.0%, with 78 strains of pathogens characterized, of which, Klebsiella pneumoniae positive in 74 cases; 100.0% sensitivity to 9 antibiotics, including cefoperazone/sulbactam; initial empirical treatment with β-lactam/enzyme inhibitor accounted for 32.2% and antimicrobial therapy switched to sensitive medicines based on drug sensitivity tests; after 13 to 25 (17.8±2.5)d treatment, the recovery rate was 94.4%, effective rate was 4.4% and one patient (1.1%)died of multiple organ failure. Conclusion The incidence of BLA is higher in middle-aged and elderly males, and most of them have underlying chronic disease. The common pathogen is Klebsiella pneumoniae, and the outcomes is satisfactory in most cases with appropriate management.

Key words: Bacterial liver abscess, Clinical ferature, Pathogens, Klebsiella pneumoniae, Antibiotic, Prognosis