Abstract: Objective The aim of this study was to summarize the etiology and clinical feature in 230 children with abnormal liver function tests. Methods The clinical data of 230 children with abnormal liver function tests, who were encountered in our hospital between October 2020 and October 2022, were retrospectively analyzed. The clinical materials were retrieved and analyzed. Results Out of the 230 children with abnormal liver function tests, the infants accounted for 53.0%, the young children for 24.8%, the preschool children for 12.6% and the school-aged for 9.6%; the clinical manifestations included fever in 156 cases(67.8%), rash in 78 cases(33.9%), cough in 66 cases(28.7%), diarrhea in 33 cases (14.3%), anorexia in 17 cases (7.4%), nausea and vomiting in 13 cases (5.7%), jaundice in 4 cases (1.7%), fatigue in 4 cases (1.7%) and without symptoms in 15 cases (6.5%); the CMV infection in 42 cases (53.2%), the EB viral infection in 22 cases(27.9%), the rotavirus infection in 7 cases (8.9%), the enterovirus infection in 4 cases (5.1%), the respiratory syncytial virus infection in 3 cases(3.8%) and the herpes simplex virus infection in 1 case (1.3%); the septicemia in 4 case, the bronchitis in 4 cases, the pharyngitis caused by Hemolytic streptococcus in 2 cases, the Neissria meningitidis meningitis in 1 case, the enteritis in 3 case; the upper respiratory mycoplasma infection in 13 cases (5.7%); the mixed virus, bacteria and mycoplasma infection in 43 cases (18.7%); the drug-induced liver injury in 33 cases (14.3%); the autoimmune hepatitis in 3 cases (1.3%); the Wilson’s disease in 7 cases, the glycogen storage disease in 3 cases; the cryptogenic liver injury in 35 cases (15.2%); serum ALT and AST levels in 22 school-aged children were(140.5±37.2)U/L and (131.3±29.7)U/L, significantly higher than in 29 preschool children or in 57 young children or [(59.4±14.8)U/L and (57.1±14.5)U/L, P<0.05] in 122 infants. Conclusion The pulmonary and gut infections could lead to transient liver injuries, with good prognosis, and needs careful screening and management.

Key words: Abnormal liver functions, Etiology, Laboratory tests, Children