Abstract: Objective The aim of this study was to investigate the implications of serum adipocytokines in patients with chronic hepatitis B（CHB）. Methods 154 patients with CHB and 154 healthy persons were recruited in our hospital between November 2014 and April 2018,and serum visfatin,leptin,adiponectin and omentin levels were detected by ELISA. All patients with CHB received liver biopsies. Results There were no significant differences as respect to serum visfatin,leptin,and adiponectin levels in patients with CHB and in healthy persons（P>0.05）,while serum omentin level in patients with CHB was（361.0±132.4） μg/L,significantly higher than （300.9±110.5） μg/L（P﹤0.05）;there were no significant differences as respect to serum visfatin,leptin,adiponectin and omentin levels in 89 patients with severe and in 65 with mild intrahepatic histological activities（P>0.05）;there were also no significant differences as respect to serum visfatin,leptin,and adiponectin in 96 patients with severe and in 58 with mild liver fibrosis（P>0.05）,while serum omentin level in patients with severe liver fibrosis was （397.8±150.4） μg/L,significantly higher than （316.7±118.5） μg/L（P﹤0.05） in patients with mild liver fibrosis. Conclusion Serum omentin levels in patients with CHB increase greatly,and might be related to the severity of liver fibrosis,which might help predict the intrahepatic liver tissue lesions in clinical practice.

Key words: Hepatitis B, Hepatic fibrosis, Adipocytokines, Liver histopathology