Abstract: Objective To investigate serum levels of Toll like receptor 4（TLR4）,transforming growth factor beta 1（TGF-β1） and interleukin-17 （IL-17） in patients with chronic hepatitis B （CHB） and hepatitis B-induced liver cirrhosis. Methods 112 patients with CHB,52 patients with hepatitis B liver cirrhosis and 33 healthy persons in our hospital between June 2015 and April 2017 were enrolled in this study. Serum IL-17, TLR4 and TGF-β1 levels were detected by enzyme linked immunosorbent assay （ELISA） and liver biopsy was performed routinely. Results Serum levels of IL-17 in patients with chronic hepatitis B,liver cirrhosis and healthy persons were（264.42±32.53） pg/ml,（271.54±33.71） pg/ml and （64.18±5.52） ng/ml,respectively,serum levels of TLR4 were （5.81±0.83） pg/ml,（37.41±6.05） pg/ml and （1.07±0.13） ng/ml respectively, and serum levels of TGF-β1 were （3.67±0.42） pg/ml,（7.82±1.07） pg/ml and （1.61±0.07） ng/ml, respectively （P<0.05）;serum IL-17,TLR4 and TGF-β1 levels in 19 patients with Child-Pugh class B were（231.38±28.67） pg/ml,（18.61±2.87）pg/ml and （5.76±0.52） ng/ml,in 16 patients with class C were（301.72±32.72） pg/ml,（39.47±6.82） pg/ml and （9.42±1.27） ng/ml,both were significantly higher than in 17 patients with Child-Pugh class A【（204.53±26.57） pg/ml,（4.72±0.71） pg/ml and（3.18±0.34）ng/ml,respectively,P<0.05】;the liver biopsies showed than liver fibrosis staging So in 8,S1 in 42,S2 in 43,S3 in 19 and S4 in 52. Serum IL-17,TLR4 and TGF-β1 levels in each group of liver fibrosis were significantly different（P<0.05）,and they increased as the pathological fibrosis stages got worse. Conclusion Serum levels of TLR4,TGF-β1 and IL-17 increase in patients with CHB and hepatitis B-induced liver cirrhosis,which might hint the diagnosis and the severity of liver cirrhosis.

Key words: Hepatitis B, Liver cirrhosis, Toll like receptor 4, Transforming growth factor beta 1, Interleukin-17