Abstract: Objective To investigate the relationship between serum insulin-like growth factor I（IGF-I） levels and intestinal barrier damage in patients with hepatitis B liver cirrhosis. Methods 107 patients with hepatitis B liver cirrhosis （35 were of Child-Pugh class A,42 of Child-Pugh class B and 30 of Child-Pugh class C） were recruited in our hospital between January 2015 and January 2017,and 40 healthy volunteers were included at the same period serving as control. Serum IGF-I,diamine oxidase（DAO）,D-lactic acid and endotoxin, as well as excretion ratio of urine lactulose/mannitol（L/M） were detected. Results Serum IGF-I level in the healthy control was （217.1±40.2） ng/ml, significantly higher than [（180.3±33.4）ng/ml in patients with Child-Pugh class A,（152.4±26.5）ng/ml in Child-Pugh class B or（126.9±21.8）ng/ml in Child-Pugh class C,all P<0.05）;serum DAO,D-lactic acid and endotoxin levels,and L/M ratio in the healthy control were （2.5±0.5） U/ml,（7.1±1.3） μg/ml and （0.4±0.1） EU/ml,and （6.3±1.1）%,significantly lower than [（3.3±0.7）U/ml,（9.0±1.6）μg/ml and （0.6±0.1）EU/ml,and （9.2±1.7）% in patients with Child-Pugh class A,or （4.6±0.9）U/ml,（11.2±1.9）μg/ml and （0.8±0.1）EU/ml,and （12.6±2.3）% in Child-Pugh class B or （5.8±1.0）U/ml,（13.4±2.4）μg/ml and（1.1±0.2）EU/ml, and（15.7±2.8）% in Child-Pugh class C, all P<0.05];serum IGF-I level in patients with liver cirrhosis was negatively correlated with serum DAO,D-lactic acid,endotoxin and urine L/M ratio（r=-0.845,r=-0.808,r=-0.867,r=-0.839, P<0.01）. Conclusion Patients with hepatitis B liver cirrhosis have damaged intestinal barrier, and serum IGF-I level might reflect it in this setting.

Key words: Liver cirrhosis, Hepatitis B, Insulin-like growth factor I, Intestinal barrier function