Abstract: Objective To compare the differences in serum liver enzymes， mortality and liver histological changes in three different strains of mice with concanavalin A（ConA） -induced acute hepatic injury （AHI）. Methods C57BL/6J mice，BABL/c mice and KM mice were subjected to ConA at four different dosages （i.e.6， 12，20 and 30 mg·kg-1） for 8 hours，and then mice were sacrificed and serum liver enzymes and liver histological changes were examined. Results ConA at dose of 6 mg·kg-1 successfully induced acute liver injury in all three strains of mice；ConA at dose of 12 mg·kg-1 caused remarkable increases in serum ALT （1006.8 ± 12.1） U/L and AST （1391.8 ± 13.4）U/L levels in KM mice，significantly higher than those in BABL/c mice [（75.7 ± 0.5） U/L and （284.7 ± 23.4） U/L，respectively and in C57BL/6J mice （104. ±32.2） U/L and （492.2 ± 12.3） U/L，respectively，P<0.05]；Similarly，liver index （5.4±0.3） and spleen index（0.7±0.5） in KM mice were significantly higher than that in BABL/c mice [（5.2±0.4） and （0.6±0.3），respectively and in C57BL/6J mice（5.0±0.6） and （0.6±0.2），respectively，P<0.05]；Serum ALT and AST levels did not differ among three strains of mice when Con A at dose of 20 mg·kg-1 was used，however，the mortality in BABL/c （4/10） and C57BL/6J（5/10） was significantly higher than that in KM mice（1/10）；30 mg·kg-1 of ConA resulted in a remarkably high mortality in all three strains of mice （30% in KM mice，100% in BABL/c and 100% in C57BL/6J mice）. Conclusion Mouse strains play a significant role in liver response to Con A，and the tolerance of KM mice to ConA is better than BABL/c and C57BL/6J mice and the liver damage is in a dose-dependent manner.

Key words: Acute liver injury, Concanavalin A, KM mice, BABL/c mice, C57BL/6J mice