Abstract: Objective To explore the change and clinical significance of coagulation function index and platelet’s parameters in patients with chronic hepatitis B.Methods 42 severe chronic hepatitis，24 acute-on-chronic liver failure，35 chronic liver failure，32 liver cirrhosis and 50 healthy peoples as control were collected. Their coagulation function index（PT，APTT，TT，Fig） and platelet’s parameters（PLT，MPV，PDW，P-LCR） were detected.Results Compared with healthy group，MPV，PDW，P-LCR increased and PLT descended in various types of chronic hepatitis groups（P<0.01）;MPV，PDW，P-LCR were higher and PLT were lower in acute-on-chronic liver failure， chronic liver failure and liver cirrhosis groups than severe chronic hepatitis group（P<0.01）;PLT，MPV，PDW in acute-on-chronic liver failure group and MPV in chronic liver failure group were higher than those in liver cirrhosis group（P<0.05，P<0.01）;There was significant difference in PLT between acute-on-chronic liver failure and chronic liver failure groups（P<0.01）;PT，APTT，TT were higher and Fig were lower in acute-on-chronic liver failure，chronic liver failure and liver cirrhosis groups than severe chronic hepatitis group（P<0.01）;Fig were lower in acute-on-chronic liver failure and chronic liver failure groups and APTT was higher in chronic liver failure group than those in liver cirrhosis group（P<0.01）.There was significant difference in APTT between acute-on-chronic liver failure and chronic liver failure groups（P<0.01）.Conclusion Coagulation and platelet parameters can reflect the degree of liver damage and bleeding tendency in patients with chronic hepatitis B.

Key words: Chronic hepatitis B, Coagulation function, Platelet parameter