Abstract: Objective To compare the predictive values of four prognostic systems including model for end stage liver disease（MELD），Child-Turcotte-Pugh（CTP），MESO and MELD-Na scoring systems in predicting the prognosis of patients with chronic severe hepatitis. Methods A cohort of 156 patients with chronic severe hepatitis were retrospectively studied and followed-up for one year. MELD，CTP，MESO and MELD-Na scores were calculated at the day of admission. Receiver operating characteristics curves（ROC）and the area under ROC（AUC） were used to determine the ability of four systems for predicting the prognosis of patients with severe hepatitis. Results The sores in dead group evaluated by MELD，CTP，MESO and MELD-Na scoring systems（31.2±6.5，12.4±1.3，2.4±0.6，and 39.4±9.8，respectively） were higher than those in survival group（20.2±7.4，10.1±1.5，1.5±0.6，and 22.5±8.6，respectively，P＜0.01）；The values of AUC of these four systems were 0.824，0.675，0.826，and 0.898，respectively. Conclusion MELD-Na system is a useful prognostic indicator for patients with chronic severe hepatitis. The MELD-Na is superior to MELS，CTP and MESO systems.

Key words: Severe hepatitis, Prognosis, Survival analysis, Risk assessment