Abstract: Objective The aim of this study was to explore clinical efficacy ofFibroTouchand virtual touch tissue quantification (VTQ) parameters in evaluating liver fibrosis in patients with schistosomiasis-induced liver disease (SILD). Methods 58 patients withSILDwere enrolled in our hospital between February 2019 and February 2023, and they all received etiological, liver-protecting and symptomatic supporting treatment. After recovery, FibroTouch was used to detect liver stiffness measurement (LSM), and VTQ was applied to detect liver shear wave velocity (SWV). Liver biopsy was performed to evaluate liver fibrosis staging, and receiver-operating characteristic curve (ROC) was adopted to analyze diagnostic performance of FibroTouch and VTQ parameters in predicting significant liver fibrosis (SLF). Results Of 58 patients with SILD, liver histo-pathological examination showed liver fibrosis S0 stage in 7 cases (12.1%), S1 stage in 15 cases (25.9%), S2 stage in 16 cases (27.6%), S3 stage in 12 cases (20.7%) and S4 stage in 8 cases (13.8%); LSM and SWV in patients with S4 liver fibrosis were (17.4±2.0)kPa and (1.9±0.2)m/s, both significantly greater than [(15.7±3.4)kPa and (1.7±0.3)m/s,P<0.05] in patients with S3 or [(12.4±2.8)kPa and (1.5±0.4)m/s, P<0.05] in those with S2 or [(8.7±2.0)kPa and (1.3±0.3)m/s, P<0.05] in S1 or [(5.8±0.9)kPa and (1.1±0.2)m/s,P<0.05] in S0; ROC analysis showed that AUCwas 0.937, with sensitivity of 87.5% and specificity of 90.0%, when LSM and SWV combination (with 12.8 kPa and 1.5 m/s as cut-off-value, respectivley) in predicting SLF in patients with SILD. Conclusion Combination of LSM and SWV in predicting SLF in patients with SILD really has certain clinical diagnostic efficacy, which might help guide clinicians to make intervention early.

Key words: Schistosomiasis-induced liver disease, Liver fibrosis, FibroTouch, Virtual touch tissue quantification, Diagnosis