Abstract: Objective The purpose of this study was to investigate anti-fibrotic efficacy of tenofovir disoproxil fumarate (TAF) and Fufang Biejia Ruangan tablet, an herbal Compound, in the treatment of patients with hepatitis B-induced liver cirrhosis (LC). Methods 116 patients with hepatitis B-induce LC were encountered in our hospital between June 2021 and June 2023, and we randomly assigned them to receive TAF (control, n=58) or TAF and herbal Compound combination (observation, n=58) for treatment of six months. Serum HBV DNA loads, and HBsAg and HBeAg levels were routinely assayed. Serumhyaluronic acid (HA), laminin (LN), procollagen type III (PIIIP) and collagen type IV (CIV) levels were detected by radioimmunoassay, and portal vein diameter (PVD), splenic vein diameter (SVD), splenic thickness (ST) and splenic length (SL) were detected by ultrasonography. Results By end of six month treatment, serum ALT level in the observation group were (43.1±6.2)U/L, much lower than [(62.6±7.8)U/L, P＜0.05]in the control, and there were no significant differences as respect to total serum bilirubin, serum albumin and INR (P>0.05)between the two groups; serum HBV DNA returned to negative, and serum HBsAg and HBeAg levels didn’t change in all patients in the two groups; serum HA,PIIIP and CIV levels in the observation were (82.2±10.3)ng/L, (94.8±11.5)ng/mL and (61.3±7.5)ng/mL, all significantly lower than [(123.1±11.9)ng/L, (132.1±13.8)ng/mLand (89.7±9.1)ng/mL, respectively, P＜0.05] in the control; SWE was (11.2±2.0)kPa, much lower than [(14.1±2.5)kPa, P＜0.05] in the control, and there were no significant differences respect to portal vein diameters and splenic vein diameters (P>0.05) between the two groups. Conclusion Administration of tenofovir disoproxil fumarate and Compound Fufang Biejia Ruangan tablets combination in the treatment of patients with hepatitis B-induced LC could improve liver function tests normal and have anti-fibrotic efficacy, which needs long-term investigation.

Key words: Liver cirrhosis, Hepatitis B, Tenofovir disoproxil fumarate, Compound Fufang Biejia Ruangan tablets, herbal medicine, Liver fibrosis, Therapy