Abstract: Objective The aim of this study was to investigate the diagnostic performance of ultrasound attenuation parameters (UAP) in predicting fatty liver diseases (FLD) in individuals at physical examination. Methods The general data, biochemical indexes, ultrasonography, UAP and liver stiffness measurement (LSM) by iLivTouch in individuals at physical examination were collected in Physical Examination Center, Third Hospital, Hebei Medical University between November and December 2020, and the diagnostic efficacy of UAP was evaluated by the area under the receiver operating characteristic curve (AUC). Results Among the 308 subjects, the FLD was found in 252 cases, with 56 persons without; the male patients with FLD accounted for the most, much greater than female patients (P<0.001), while there was no significant difference as respect to ages between the those with and without FLD (P>0.05); serum HDL level in patients with FLD was significantly lower than, while the BMI, serum TG, TC, LDL, VLDL, ALT, AST, Cr, UA, GLU and UAP were significantly higher than those in healthy persons (P<0.05); the BMI, ALT and UA were the independent predictors for higher UAP, and the cut-off value was 251.35 dB/m, with the AUC of 0.856, the sensitivity of 0.710 and the specificity of 0.839, when the UAP was applied to diagnose the FLD; the diagnostic performance by the combination of UAP, BMI and ALT for FLD with AUC of 0.920 was superior to any parameter done alone. Conclusion The UAP obtained by iLivTouch scam could diagnose the FLD, and it might be helpful to take the BMI and serum ALT into consideration.

Key words: Fatty liver diseases, Ultrasound attenuation parameter, iLivTouch, Diagnosis