Abstract: Objective The aim of this study was to investigate the diagnostic efficacy of significant liver fibrosis (SLF) by two-dimensional shear wave elastography (SWE) andγ-glutamyltransferase (GGT)/platelet (PLT) ratio (GPR) in patients with chronic hepatitis B (CHB). Methods 130 patients with CHB were encountered in our hospital between February 2021 and December 2022, and all underwent liver biopsy. The Young's modulus of livers was detected by SWE of ultrasonography, serum GGT levels and whole blood PLT counts were detected routinely, and the GPR was calculated. The consistency between the Young's modulus and GPR and the pathological diagnosis was evaluated by Kappa test, and the diagnostic efficacy was assessed by the area under the receiver operating characteristic curve (AUROCs). Results Out of the 130 patients with CHB, the liver histopathological examination showed F0, F1, F2, F3 and F4 in 93 cases, 14 cases, 8 cases, 12 cases and 3 cases, with SLF in 23 cases; the GPR and the Young's modulus in patients with stage F3 liver fibrosis were 0.5(0.4, 0.7) and (10.4±1.5)kPa, and in patients with F2 were 0.4(0.3, 0.6) and (8.9±1.6)kPa, all significantly greater than [0.4(0.3, 0.5) and (7.3±1.2)kPa, respectively, P<0.05] in patients with F1; the AUROCs analysis showed the good consistency between the Young's modulus, GPR or the combination of the two parameters, and the pathological diagnosis (Kappa=0.42, Kappa=0.50 and Kappa=0.63, respectively, P＜0.05); the AUC was 0.83 (95%CI:0.76-0.94), with the sensitivity and the specificity of 83.8% and 83.9% by the combination of GPR and Young's modulus in predicting SLF in patients with CHB, much superior to that by any one of the two alone(P＜0.05). Conclusion The GPR and the SWE by ultrasonography might be applied to predict the SLF in patients with CHB clinically, and warrants further investigation.

Key words: Hepatitis B, Liver fibrosis, Shear wave elastography, γ- glutamyltransferase / platelet ratio, Diagnosis