Abstract: Objective The aim of this study was to explore the clinical implication of peripheral blood derived neutrophil to lymphocyte ratio (dNLR), monocyte to lymphocyte ratio (MLR) and systemic immune inflammatory index (SII) in patients with hepatitis B liver cirrhosis(LC). Methods 85 patients with hepatitis B-induced LC and 85 patients with chronic hepatitis B (CHB) were encountered in our hospital between January 2019 and December 2021. Serum tumor necrosis factor -α(TNF-α), interleukin-6 (IL-6) and IL-17 levels were detected by ELISA. The peripheral blood platelet, lymphocyte, neutrophil and monocyte counts were detected by full-automatic blood cell analyzer. Results Serum bilirubin level and INR in patients with LC were(43.1±8.5)μmol/L and (1.3±0.6), much higher than [(19.4±3.0)μmol/L and (1.1±0.2), P＜0.05], while serum ALT and albumin levels were (63.6±8.2)U/L and (30.8±4.6)g/L, much lower than [(104.1±14.9)U/L and (39.0±8.1)g/L, respectively, P＜0.05] in patients with CHB; serum TNF-α, IL-6 and IL-17 levels in patients with LC were (88.7±11.6)pg/mL, (95.6±12.5)pg/mL and (45.6±8.9)ng/mL, significantly higher than [(68.2±9.3)pg/mL, (67.9±9.5)pg/mL and (25.5±5.1)ng/mL, respectively, P＜0.05] in patients with CHB; the dNLR, MLR and SII in patients with (2.2±0.5), 0.8(0.7, 0.9) and (553.9±83.4), significantly higher than [(1.8±0.3), 0.6(0.5, 0.7) and (481.4±99.3), P＜0.05] in patients with CHB; the dNLR, MLR and SII in LC patients with Child class B/C were significantly higher than in those with Child class A(P＜0.05), and the dNLR, MLR and SII in patients with Child class C were significantly higher than in patients with Child class B (P＜0.05). Conclusion The peripheral blood dNLR, MLR and SII significantly increase in patients with hepatitis B cirrhosis, and their changes are related to disease severity.

Key words: Liver cirrhosis, Derived neutrophil to lymphocyte ratio, Monocyte to lymphocyte ratio, Systemic immune inflammatory index, Child-Pugh classification