Abstract: Objective The aim of this study was to investigate the short-term efficacy of biliary-enteric Roux-en-Y anastomosis and indwelling subcutaneous jejunal blind loop combination in the treatment of patients with intrahepatic bile duct stones (IHS). Methods 71 patients with IHS were enrolled in our hospital between September 2018 and June 2021, and 33 patients in control group were treated by conventional biliary-enteric Roux-en-Y anastomosis, and another 38 patients in observation group were treated with biliary-enteric Roux-en-Y anastomosis and indwelling subcutaneous jejunal blind loop combination. Serum total bilirubin (TBIL), alkaline phosphatase (ALP), alanine aminotransferase (ALT) and glutamyltransferase (GGT) levels were obtained. Serum C-reactive protein (CRP) and interleukin-6 (IL-6) levels were detected by ELISA, and serum procalcitonin (PCT) level was assayed by automatic fluorescent immunoquantitative analyzer. Results At the end of one month after surgery, the clinically total effective rate in the observation group was 94.7%, significantly higher than 75.8%(P<0.05) in the control group; serum GGT and ALT levels in the observation groups were (71.9±6.2)U/L and (38.7±5.9)U/L, significantly lower than [(95.8±6.9)U/L and (62.6±6.8)U/L, respectively, P<0.05] in the control; serum CRP and IL-6 levels were (60.8±8.1)mg/L and (89.8±20.1)pg/mL, significantly higher than [(38.3±9.2)mg/L and (65.7±23.5)pg/mL, respectively, P<0.05] in the control; the postoperative residual of stones in the observation group was significantly less than that in the control group (7.9% vs. 21.2%, P<0.05). Conclusion The combination of iliary-enteric Roux-en-Y anastomosis and indwelling subcutaneous jejunal blind loop in the treatment of patients with IHS has a good clinical efficacy, which might prevent the postoperative reflux infection and reduce the occurrence of postoperative stone residual, providing a permanent access to the intrahepatic bile duct for recurrent stones.

Key words: Intrahepatic bile duct stones, Biliary-enteric Roux-en-Y anastomosis, Indwelling subcutaneous jejunal blind loop, Therapy