Abstract: Objective The aim of this study was to investigate the efficacy of indwelling subcutaneous jejunal blind loop and Roux-en-Y choledochojejunostomy in treatment of patients with hepatolithiasis. Methods 74 patients with hepatolithiasis were admitted to our hospital between September 2017 and September 2020, andwere randomly divided into control and observation group, with 37 cases in each, receiving Roux-en-Y choledochojejunostomy or Roux-en-Y choledochojejunostomy and indwelling subcutaneous jejunal blind loop thereafter. Serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels were detected by ELISA. Results The operation time in the observation group was (265.4±27.1) min, significantly longer than [(243.5±25.6) min, P<0.05] in the control group; after the operation, total serum bilirubin, alanine aminotransferase and gamma-glutamyltransferase levels in the two groups decreased greatly, and no significant differences among them between the two groups (P>0.05); the white blood cell counts, serum IL-6 and TNF-α levels decreased greatly, and no significant differences among them between the two groups (P>0.05); during the follow-up periods, 14 patients out of our series had second or more time operations to remove the stones, of which 3 cases(8.1%) from the observation and 11 cases (29.7%, P＜0.05) from the control. Conclusion The procedure of indwelling subcutaneous jejunal blind loop after Roux-en-Y choledochojejunostomy is beneficial to repeated removing stones from intrahepatic bile ducts, which warrants further investigation.

Key words: Hepatolithiasis, Roux-en-Y choledochojejunostomy, Indwelling subcutaneous jejunal blind loop, Therapy