血液抽吸联合射频消融治疗肝血管瘤患者疗效研究*

doi:10.3969/j.issn.1672-5069.2022.05.030

Abstract

Abstract: Objective The purpose of this study was to compare the short-term efficacy of intratumor blood aspiration and radiofrequency ablation (RFA), and transcatheter arterial embolization (TAE) in the treatment of patients with hepatic hemangioma (HCH). Methods 102 patients with HCH were encountered in our hospital between October 2018 and October 2020, and the RFA after intratumor blood aspiration was conducted in 46 patients and the TAE was performed in 56 patients. All patients were followed-up for three months. Results The operative time, intraoperative blood loss and hospital stay in patients with TAE operation were (49.2±14.6) min, (13.4±3.7) mL and (3.4±1.6) days, significantly different compared to (57.5±18.9)min, (7.5±1.9)mL and (1.5±0.5)days, respectively, in patients receiving RFA after intratumor blood aspiration (P＜0.05); at the moment immediately after operation and the end of three months, the tumor volumes in TAE-treated patients were (49.2±22.5) mL and (31.4±15.7) mL, not significantly different as compared to (49.1±22.3)mL and (31.2±15.5)mL in RFA-treated patients (P>0.05), and so were the tumor shrinkage rates in the two groups (P>0.05); after operation, the complications in TAE-treated patients was 17.9%, much higher than 6.5%(P＜0.05) in RFA-treated patients. Conclusion The short-term efficacy of RFA after intratumor blood aspiration or TAE in the treatment of patients with HCH is good, and the RFA treatment has less post-operationally complications.

Key words: Hepatic hemangioma, Transcatheter arterial embolization, Radiofrequency ablation, Blood aspiration, Therapy

Ren Wenyan, Zhao Sen, Zhuang Yan et al.. Short-term efficacy of intratumor blood aspiration and radiofrequency ablation in the treatment of patients with hepatic hemangioma[J]. Journal of Practical Hepatology, 2022, 25(5): 726-729.

References

[1]Turkyilmaz G , Sivrikoz T S , Kalelioglu I , et al. Prenatal diagnosis of fetal liver hemangioma. Ultrasound Obst Gyn, 2016, 48(1):306-307.
[2]Duan J . Microimaging for different degrees of human cavernous hemangioma of liver by using in-line phase contrast imaging CT. Med Phys, 2016, 43(6):3679-3680.
[3]Portolani N , Baiocchi G , Gheza F , et al. Impact on liver cancer treatment of a first erroneous diagnosis of hemangioma. World J Surg, 2014, 38(10):2685-2691.
[4]Juan-Carlos A, López-Gutiérrez H. Clinical and economic impact of surgery for treating infantile hemangiomas in the era of propranolol: overview of single-center experience from La Paz hospital, Madrid. Eur J Pediatr, 2018, 178(1):1-6.
[5]王勋, 陈明易, 陈永卫,等. 外科手术治疗肝脏血管瘤908例临床分析. 中华肝胆外科杂志, 2018, 24(7):442-445.
[6]Park S Y , Tak W Y , Jung M K , et al. Symptomatic-enlarging hepatic hemangiomas are effectively treated by percutaneous ultrasonography-guided radiofrequency ablation. J Hepatol, 2011, 54(3):559-565.
[7]Gao J , Ding X , Ke S , et al. Radiofrequency ablation in the treatment of large hepatic hemangiomas: a comparison of multitined and internally cooled electrodes. J Clin Gastroenterol, 2014, 48(6):540-547.
[8]Lyu P , Lin X Z , Li J , et al. Differentiation of small hepatic hemangioma from small hepatocellular carcinoma: recently introduced spectral CT method. Radiology, 2011, 259(3):720-729.
[9]Tenkumo C , Hanaoka U , Aboellail M A M , et al. Hdlive flow with hdlive silhouette mode in diagnosis of fetal hepatic hemangioma. Ultrasound Obstet Gynecol, 2017, 49(4):541-542.
[10] Toro A , Mahfouz A E , Ardiri A , et al. What is changing in indications and treatment of hepatic hemangiomas. A review. Ann Hepatol, 2014, 13(4):327-339.
[11] Billio A, Pescosta N, Rosanell C, et al. Treatment of Kasabach-Merritt syndrome by embolisation of a giant liver hemangioma. Am J Hematol,2001,66(2):140-141.
[12] Takahashi H , Akyuz M , Aksoy E , et al. Local recurrence after laparoscopic radiofrequency ablation of malignant liver tumors: results of a contemporary series. J Surg Oncol, 2017, 115(7):830-834.
[13] Federle M P , Brancatelli G , Blachar A . Hepatic hemangioma. N Engl J Med, 2000, 343(5):368-369.
[14] 袁冰, 张金龙, 袁凯,等. 应用博来霉素行超选择性肝动脉栓塞术治疗肝血管瘤. 中华肝胆外科杂志, 2018, 24(8):510-513.
[15] Ypsilantis P , Didilis V , Eleftheriadis S , et al. Early hemodynamic effects after extended liver radiofrequency ablation. Jo Surg Res, 2015, 195(1):204-210.
[16] Goto E , Tateishi R , Shiina S , et al. Hemorrhagic complications of percutaneous radiofrequency ablation for liver tumors. J Clin Gastroenterol, 2010, 44(5):374-380.
[17] 杜英瑞, 柯山, 高君,等.射频消融治疗肝脏良性占位性病变的现状及进展.中华肝胆外科杂志,2018, 24(4):283-286.
[18] 周成明, 张金辉, 任伟新, 等. 514例肝血管瘤的治疗与临床评分. 中华消化外科杂志, 2015, 14(2):102-105.
[19] Hiroyuki MJ, Sugo LY, Yuki S, et al. Hepatic sclerosing hemangioma with predominance of the sclerosed area mimicking a biliary cystadenocarcinoma. Case Rep Hepatol, 2018, 20(1):7353-7357.
[20] 王劭宏, 高君, 柯山,等.射频消融治疗肝脏巨大血管瘤的疗效及安全性.中华普通外科杂志,2014, 29(3):172-176.

Short-term efficacy of intratumor blood aspiration and radiofrequency ablation in the treatment of patients with hepatic hemangioma

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