Abstract: Objective The purpose of this study was to analyze the factors impacting duration of percutaneous transhepatic biliary drainage (PTBD) in patients with choledocholithiasis. Methods A total of 112 patients with common bile duct stones (CBDS) were encountered in our hospital between April 2019 and March 2021, and all patients were treated with PTBD. The patients were divided post-operationally into normal biliary drainage group with mean plus deviation drainage time and prolonged drainage group with longer drainage time. The factors impacting the duration of PTBD in patients with CBDS were analyzed by multivariate Logistic regression. Results Out of the 112 patients with CBDS, the biliary stones were successfully removed in 109 patients(97.3%), with prolonged biliary drainage time in 28 cases; there were significant differences as respect to serum bilirubin levels [(38.1±7.3)μmol/L vs. (24.2±6.2)μmol/L], serum amylase levels [(403.7±15.6)U/L vs.(92.7±13.2)U/L], serum ALP levels [(302.3±52.1)U/L vs. (180.7±50.2)U/L], serum GGT levels [(176.6±16.7)U/L vs. (93.3±15.6)U/L], serum C-reactive proteins [(75.1±12.2)mg/L vs. (56.9±10.3)mg/L] and the diameters of stones [(16.9±2.5)mm vs. (11.3±2.1)mm] between the two groups(P＜0.05); the multivariate Logistic analysis showed that serum bilirubin levels (OR:4.092, 95%CI:1.684-9.944), serum amylase levels (OR:3.277, 95%CI: 1.348-7.965) and the diameter of stones (OR:3.651, 95%CI:1.502-8.873) were the risk factors impacting the duration of biliary drainage(P＜0.05). Conclusion The treatment of patients with CBDS by PTBD is successful, and our findings suggest the clinicians should take influencing factors of biliary drainage time into consideration in clinical practice in order to manage appropriately pre-operationally.

Key words: Choledocholithiasis, Percutaneous transhepatic biliary drainage, Drainage time, Influencing factors