Journal of Practical Hepatology ›› 2022, Vol. 25 ›› Issue (1): 144-147.doi: 10.3969/j.issn.1672-5069.2022.01.036

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Administration of non-selective beta-blockers in treatment of patients with liver cirrhosis and portal hypertension

Wu Ling, Li Feng   

  1. Department of Gastroenterology and Hepatology,Zhongshan Hospital,Fudan University,Shanghai 200032,China
  • Received:2020-02-24 Published:2022-01-12

Abstract: Objective The liver cirrhosis (LC) is the consequence of various chronic liver diseases, with liver function abnormality and portal hypertension occurring in the decompensatory stage. The non-selective beta-blockers (NSBB) has been one of the main medicine for patients with portal hypertension in almost 3 decades, inasmuch as its capacity in reducing portal pressure, though, at the same time, the hemodynamic effects of NSBB can influence the circulatory function of patients. When and how to prescribe NSBB depends on patients' conditions. We aimed to review the reasonable application and controversy of NSBB treatment in cirrhotic patients.

Key words: Liver cirrhosis, Portal hypertension, Non-selective beta-blockers, Adrenergic beta-antagonists