Abstract: Objective The aim of this study was to analyze the dyslipidemia in patients with liver cirrhosis (LC). Methods A total of 448 patients with LC were admitted to our hospital between January 2013 and December 2017, and included hepatitis B in 194, hepatitis C in 20, alcohol-induced in 46, hepatitis B or C with alcohol in 41, cryptogenic in 85, autoimmune hepatitis in 33, NAFLD in 10 and schistosomiasis in 19 cases. The blood lipid were analyzed, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low density lipoprotein (LDL), apolipoprotein A (APOA) and apolipoprotein B (APOB). Results Out of the 448 patients with LC, 221 cases (49.3%) had dyslipidemia, and the majority of dyslipidemia was low HDL (n=207, 93.7%); the mixed hyperlipidemia was the least (n=1, 0.5%);the blood TC in 186 patients with Child class A was (3.8±0.9) mmol/L, significantly higher than [(3.4±1.3) mmol/L,P<0.01] in 183 patients with class B, or [(3.1±1.3) mmol/L, P <0.01] in 79 patients with class C; the blood TG in class A was (1.1±0.6) mmol/L, significantly higher than [(0.9±0.5) mmol/L, P <0.05] in class B, or [(0.9±0.5) mmol/L, P <0.01] in class C; the HDL level was (1.3±0.4) mmol/L, significantly higher than [(1.1±0.4) mmol/L, P <0.01] in class B, or [(0.8±0.4) mmol/L, P <0.01] in class C; the LDL was (2.1±0.6) mmol/L, significantly higher than [(1.8±0.9) mmol/L, P <0.01] in class B, or [(1.7±0.8) mmol/L, P <0.01] in class C; the APOA was (1.1±0.3) mmol/L, significantly higher than [(0.9±0.3) mmol/L, P <0.01] in class B, or [(0.8±1.3) mmol/L, P <0.01] in class C; the APOB was (0.7±0.2) mmol/L, significantly higher than [(0.6±0.3) mmol/L, P <0.01] in class B; the proportion of dyslipidemia increased significantly with the Child-Pugh classification deteriorated, e.g., the percentages of dyslipidemia was 32.3% in class A, 52.5% in class B, and 82.3% in class C (P <0.01); the dyslipidemia was most common in patients with NAFLD associated (60.0%) and hepatitis C-induced LC (60.0%), and relatively less common in hepatitis B-induced (43.8%). Conclusion Low HDL level is the most common type of dyslipidemia in patients with LC, and as the liver function deteriorates, it becomes common.

Key words: Liver cirrhosis, Blood lipid, Child-Pugh classification