Abstract: Objective The purpose of this study was to analyze the risk factors of acute kidney injury (AKI) in patients with hepatitis B-induced liver cirrhosis (LC). Methods 136 patients with hepatitis B-induced LC were admitted to our hospital between March 2018 and March 2020, and the clinical data were retrieved from HIS system. The AKI in 40 patients was diagnosed met with related guidelines, and the Logistic regression was applied to analyze the risk factors that affect the occurrence of AKI. Results The univariate analysis showed that the percentage of decompensated liver cirrhosis in patients with AKI was 52.5%, significantly higher than 31.3%(P<0.05) in those without, the incidence of ascites was 55.0%, significantly higher than 29.2%(P<0.05) in patients without AKI, and the hepatic encephalopathy was 22.5%, significantly higher than 4.2%(P<0.05) in those without, while there were no significant differences respect to age, gender, disease course and Child-Pugh class between the two groups (P>0.05); the multivariate Logistic regression analysis showed that compensated or decompensated liver functions, ascites, and hepatic encephalopathy were the independent risk factors for AKI occurrence in patients with hepatitis B-induced LC (P<0.05). Conclusion The patients with hepatitis B-induced LC might have AKI, especially in those with risk factors such as decompensated liver cirrhosis, ascites and complicated hepatic encephalopathy.

Key words: Liver cirrhosis, Acute kidney injury, Risk factors, Multivariate Logistic regression analysis