Abstract: Objective The aim of this study was to compare the curative efficacy of laparoscopic-choledochoscopic cholelithotomy and laparoscopic cholecystectomy (LC) in patients with gallbladder stones. Methods 78 patients with gallbladder stones were admitted to our hospital between February 2015 and February 2020, and out of them, 36 patients underwent laparoscopic-choledochoscopic cholelithotomy and 42 patients underwent LC. They were followed up for 12 months after surgery. Serum cortisol and C-reactive protein (CRP) levels were detected by ELISA or double-antibody sandwich immunoluminescence assay. Results The operation time and hospitalization cost in observation group were (53.3±17.7) min and (3.2±0.5) ten thousand yuan, significantly longer or higher than [(36.7±10.8) min and (2.3±0.4) ten thousand yuan, P<0.05], and the postoperative eating time and anal exhaust time were (2.8±0.9) h and (14.9±3.2) h, significantly shorter than [(3.3±0.7) h and (19.3±4.1) h, respectively, P<0.05] in the control; 3 days after surgery, serum CRP and COR levels in the observation group were (11.2±3.1) mg/L and (195.6±30.8) ng/mL, significantly lower than [(19.0±4.9) mg/L and (211.6±32.7) ng/mL, respectively, P<0.05] in the control; the ultrasonography 2 weeks after surgery showed that there were no residual stones in the observation group, and the gallbladder function was intact; at 3 months of follow-up, the incidence of complications, such as incision infection, abdominal distension and diarrhea, reflux gastritis, biliary hemorrhage and acute pancreatitis in the observation group was significantly lower than that in the control group (11.1% vs. 31.0%, P<0.05); at the end of 12-month follow-up, one patient (2.8%) had stone recurrence. Conclusion The application of laparoscopic-choledochoscopic cholelithotomy in the treatment of patients with gallbladder stone might be more beneficial to the recovery of gastrointestinal functions with less postoperative complications.

Key words: Gallbladder stone, Laparoscopic-choledochoscopic cholelithotomy, Laparoscopic cholecystectomy, Therapy