Abstract: Objective The purpose of this study was to investigate the clinical value of transient elastography (TE) and two-dimensional shear wave elastography (SWE) in the diagnosis of liver fibrosis in patients with chronic hepatitis B (CHB). Methods 164 patients with CHB B were enrolled in our hospital between March 2016 and December 2018, and all patients underwent HE and SWE. The liver biopsy was also performed. The area under ROC curve (AUC) was applied to analyze the diagnostic performance. Results The liver histopathological examination showed liver fibrosis S₁ in 50, S₂ in 42, S₃ in 39 and S₄ in 33 in our series; the liver stiffness measurement (LSM) of patients with S₁, S₂,S₃ and S₄ by TE were (6.5±1.1)kPa, (8.6±1.4)kPa, (11.7±1.8)kPa and (16.3±1.8)kPa, and by SWE were (5.9±0.8) kPa, (8.1±1.2)kPa, (10.9±1.5)kPa and (16.7±1.9) kPa(P >0.05); the AUC of SWE in diagnosing S₂, S₃ and S₄ were 0.971, 0.979 and 0.973, much higher than 0.902, 0.906 and 0.904(P <0.05) by TE, and the sensitivities were 90.3%, 90.6% and 100.0%, and the specificities were 95.8%, 90.6% and 84.5%, while they were 78. 5%, 81.3% and 73.1%, and 93.3%, 87.9% and 91.0%, respectively, by TE. Conclusion The application of TE and SWE in the diagnosis of liver fibrosis in patients with CHB might possess a efficient performance in clinical practice.

Key words: Hepatitis B, Transient elastography, Two-dimensional shear wave elastography, Hepatic fibrosis, Diagnosis