Abstract: Objective To analyze serum biochemical indexes of patients with alcoholic cirrhosis （AC） with or without ascites.Methods A total of 103 patients with AC were chosen in our hospital between January 2012 and September 2016. There were 33 patients without，and 70 with ascites. The clinical datas of demographics，coagulation function，liver function，routine blood tests，and tumor markers were collected，and analyzed by Student’s t or Mann-Whitney U tests. Result The majority of patients with AC were man with the peak of incidence in the age from 40 to 60 years old. serum levels of PT-S，APTT，TT，INR and D-h in AC patients without ascites were（17.5±3.5） s，（33.3±4.6） s，（17.0±1.9） s，（1.3±0.3） and（749.8±1246.9） μg/L，respectively，much lower than those in with ascites [（22.3±7.2） s，（39.2±10.5） s，（19.1±4.7） s，（1.7±0.7） and （1330.4±1402.4） μg/L，respectively，P<0.05]；serum levels of ALB and blood RBC and HGB in AC patients without ascites were （35.1±5.2） g/L，（3.6±0.9）×1012/L and （120.7±30.0） g/L，respectively，much higher than those in with ascites [（30.6±6.2） g/L，（3.0±0.8）×1012/L and（101.7±30.1） g/L，respectively，P<0.05]；serum levels of CA125 in AC patients without ascites was （93.4±128.4） U/ml， much lower than that in ascites group [（468.1±498.4） U/ml， P<0.05].Conclusion There might exist differences between serum and blood parameters in patients with AC with and without ascites，which warrants surveillance of them in evaluating disease severity.

Key words: Alcoholic cirrhosis, Ascites, Serological indicators