JOURNAL OF PRACTICAL HEPATOLOGY ›› 2017, Vol. 20 ›› Issue (2): 175-178.doi: 10.3969/j.issn.1672-5069.2017.02.012

Previous Articles     Next Articles

Predictive value of Fibrotouch combined with FIB-4 index in prediction of complications in patients with liver cirrhosis

Liu Yan,Zhao Weifeng,Gan Jianhe, et al   

  1. Department of Infectious Diseases,First People’s Hospital, Taicang 215400,Jiangsu Province,China
  • Received:2016-07-07 Online:2017-04-10 Published:2017-06-07

Abstract: Objective To evaluate the predictive value of complications by Fibrotouch combined with FIB-4 index in patients with liver cirrhosis.Methods Between June 2015 and February 2016, the patients with liver cirrhosis in our hospital were recruited in this study. Fibrotouch was applied to detect the liver stiffness measurement(LSM),and FIB-4 index was calculated. The differences in LSM and FIB-4 index among patients with different Child-Pugh class,patients with compensated or decompensated cirrhosis and patients with single complications or multiple complications were analyzed. Logistic analysis was used to predict the risk for occurrence of complications,and receiver operating characteristic curves were used to evaluate its predictive value.Results The LSM in patients with Child-Pugh class A was (17.09±7.15) kPa,significantly lower than that in with Child-Pugh class B [(27.37±5.83)kPa,P<0.01] or that in with Child-Pugh class C[(34.26±9.10) kPa,P<0.01];the FIB-4 index in patients with Child-Pugh class A was(3.69±2.66),significantly lower than that in with Child-Pugh class B[(6.67±4.30),P<0.01] or that in with Child-Pugh class C[(8.49±4.69),P<0.01];The LSM in compensated cirrhosis patients was(17.14±7.27)kPa,significantly lower than that in the decompensated cirrhosis patients [(29.11±7.79)kPa,P<0.01];the FIB-4 index in compensated cirrhosis patients was (3.66±2.70),significantly lower than that in the decompensated cirrhosis patients[(7.14±4.44),P<0.01];The LSM in patients with single complication was(26.98±6.03)kPa,significantly lower than that in with multiple complications [(34.95±9.12)kPa,P<0.01];the FIB-4 index in single complication patients was (6.56±4.22),significantly lower than that in multiple complications patients[(8.74±4.72),P<0.01];The AUC of Fibrotouch combined with FIB-4 index to predict complications in patients with liver cirrhosis was 0.903,significantly higher than that by FIB-4 index alone(0.765,P<0.01).Conclusion Fibrotouch combined with FIB-4 index can improve the predictive value of complications in patients with liver cirrhosis,which is worthy of clinical application.

Key words: Liver cirrhosis, Complications, Transient elastic imaging technology, FIB-4 index, Diagnosis