Abstract: Objective To investigate the clinical characteristics of patients with chronic hepatitis C（CHC） with concomitant type 2 diabetes and to assess the impact of insulin resistance（IR） on sustained virological response （SVR） in patients with hepatitis C to treatment of interferon-α（IFN-α）. Methods A systematic search of electronic databases for randomized clinical trials in Pubmed,Ovid,Science Direct,Embase,Wanfang database and VIP database from 1970 to January,2015 was done as respect to clinical features of CHC with type 2 diabetes,and the correlation between IR and SVR. The Meta analysis was performed by using the RevMan 5.2 software. Result Twenty-two papers published in English were retrieved in this study,with eleven on CHC with type two diabetes,and eleven on IR impacting response to IFN-α therapy. Patients with CHC and type 2 diabetes had older age and higher BMI than in patients with CHC or diabetes alone [P=0.0001,SMD=0.30,95%CI （0.15,0.45）,P=0.04,SMD=0.17,95%CI（0.01,0.34）];More patients with CHC and type 2 diabetes had family history of diabetis than in patients with CHC or diabetes alone[P=0.01,RR=1.07,95%CI（1.02,1.13）];The incidence of genotype 1 infection in CHC patients with type 2 diabetes was significantly lower than in that of CHC alone[P=0.01,RR=0.82,95%CI（0.71,0.95）],while there was no significant differences as respect of genotypes 2/3 infection in the two groups[P=0.25,RR=1.16,95%CI（0.90,1.50）,P=0.92,RR=1.06,95%CI （0.30,3.78）];The incidence of IR was higher in CHC patients with non-sustained virological response（NSVR） to interferon-α therapy than in those who got SVR [P<0.0001,SMD=0.80,95%CI（0.63,0.97）,P<0.0001,OR=2.0,95%CI （1.59,2.52）]. Conclusion s Patients with CHC and type 2 diabetes tends to be elderly with higher BMI levels and much more family history of diabetes. IR is associated with a lower SVR in CHC patients receiving IFN-α therapy.

Key words: Hepatitis C, Type 2 diabetes, Interferon-α, Genotypes, Insulin resistance