Nrf2信号通路与肝细胞凋亡研究进展

doi:10.3969/j.issn.1672-5069.2016.03.031

Abstract

Abstract: Hepatocyte apoptosis can be divided into physiological and pathologicalapoptosis. Both of them are relevant to the progression of liver disease. Reactive oxygen species（ROS） play an important role in the induction of hepatocyteapoptosis. Recently， some reports show thatnuclear factor E2-related fator 2（Nrf-2） represents one of the mostimportant cellular defense mechanisms against oxidative stress，inflammatory and tumorigenesis. Here，we reviewed the mechanisms of signal transduction involved in Nrf-2 related pathway and its possible roles in the process of hepatic apoptosis under oxidative stress.

Key words: Hepatocytes, Apoptosis, Reactive oxygen species, Nuclear factor E2-related fator 2

Cui Dan,Yang Baoshan. Role of Nrf2 in the regulation of hepatocyte apoptosis[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2016, 19(3): 365-368.

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Role of Nrf2 in the regulation of hepatocyte apoptosis

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