Abstract: Objective To investigate serum levels of soluble endogin （sEng） and its clinical significance in the patients with liver cirrhosis and hepatocellular carcinoma（HCC）. Methods From June 2009 to June 2014， 77 patients with HBV related liver cirrhosis，54 patients with HCC and 36 healthy individuals who had been treated in our hospital were enrolled in this study. The serum levels of alpha fetoprotein（AFP） were assayed by chemiluminescent immunoassay and the serum levels of sEng were detected by enzyme-linked immunosorbent assay. The correlations of sEng and clinical indexes were analyzed by Pearson or Spearman correlation analysis.Furthermore，the diagnostic values of sEng and AFP for HCC were analyzed with ROC curve，and the patients with HCC with different levels of sEng were followed up for three years. Results Serum level of sEng in patients with HCC[19.71（15.16～23.56） ng/L] were significantly higher than that in patients with liver cirrhosis [6.42 ng/L （4.23～9.89）ng/L] or in healthy controls [2.83（2.28～3.30） ng/L，P<0.05]；there was a significant positive correlation between serum sEng and serum AFP in patients with HCC（r=0.660，P<0.001）；the area under curve（AUC） in discriminating HCC from health control by sEng or sEng with AFP were 0.912（95%CI: 0.851～0.973） and 0.951 （95%CI:0.911～0.992）；the AUC in discriminating HCC from cirrhosis by sEng or sEng with AFP were 0.849 （95%CI:0.778～0.920） and 0.920 （95%CI:0.867～0.972）；3 a overall survival rates were 24.0% in HCC patients with serum sEng≥20.0 ng/L and 41.4% in HCC patients with serum sEng<20.0 ng/L，respectively（P<0.05）. Conclusion The detection of serum sEng can not only improve the diagnosis of HCC，but also has a certain value in prognosis of patients with HCC in clinical practice.

Key words: Cirrhosis, Hepatocellular carcinoma, Endoglin, Alpha-fetoprotein, Diagnosis, Prognosis