Abstract: Hepatocellular carcinoma （HCC） is the fifth most common cancer and the third most common cause of the tumor-related death worldwide. Because of the absence of clinical symptoms at the early stage,the majority of patients are diagnosed at the intermediate/advanced stage when the options of curative treatments are limited.The approaches for the treatment of primary liver cancer are transcatheter arterial chemoembolization, ablation radiotherapy, chemotherapy,and targeted molecular therapy. These therapeutic methods, either alone or in combination, have been proven to control the tumor growth, prolong survival, and improve quality of life to some extent.

Key words: Hepatocellular carcinoma, Non-surgical management, Progress