Abstract: Objective To investigate the efficacy of intrahepatic transplantation of autologous bone marrow mesenchymal stem cells （BMSCs） in the treatment of patients with decompensated alcohol-induced liver cirrhosis （ALC）. Methods Twenty-eight patients with decompensated alcohol-induced liver cirrhosis were recruited for intrahepatic transplantation of BMSCs from 2007 to 2012,and other 28 patients with ALC were selected by propensity scores matching for age,gender and complications of liver cirrhosis. Results The serum alanine aminotransferase levels declined to nearly normal levels,total bilirubin decreased,albumin（ALB） increased, prothrombin times shorten,and Child-Pugh scores（CPS） were improved gradually;The model of end stage liver disease scores were significant decreased to（20.6±5.2） at forth week,and significantly lower than in the control group（P=0.009）,however,there was no remarkable differences after 72 weeks （P=0.536） between the two groups;The survival rates at 144 weeks in the two groups were not significantly different （32.1% vs. 25.6%,P=0.125）;Further analysis showed that the survival rates in patients with CPS class B in the two groups were significantly different （66.7% vs. 36.4%,P=0.046）,while there was no significant difference in patients with CPS class C （12.5% vs. 17.6%,P=0.788）. Conclusions The short-term efficacy of BMSCs transplantation in the treatment of patients with decompensated ALC is favorable,but the long-term efficacy needs further investigation.

Key words: Alcohol-induced liver cirrhosis, Autologous bone marrow mesenchymal stem cells, Transplantation, Efficacy