Abstract: Objective To observe the efficacy of patients with decompensated hepatitis B cirrhosis after splenectomy or partial splenic artery embolization. Methods 108 patients with decompensated hepatitis B-related liver cirrhosis were recruited in this study,and 50 received splenectomy,28 received partial splenic artery embolization and 30 received conventional medical therapy as control. Results At the end of one-year follow-up,the peripheral white blood cell and platelet counts in control group were（3.3±0.6）×10⁹/L and（56.3±5.8）×10⁹/L,significantly lower than in spleen resection group（6.2±0.6）×10⁹/L and（126.5±12.7）×10⁹/L（P<0.05）,or in partial splenic artery embolization group（7.2±0.8）×10⁹/L and （112.8±10.6）×10⁹/L（P<0.05）;the peripheral blood CD₄,CD₄/CD₈ ratio and albumin levels were（32.5±3.5）%,（1.1±0.2）and （24.9±3.8） g/L,significantly lower than in patients with splenectomy（41.8±4.2） %,（1.9±0.2） and （29.1±3.7） g/L（P<0.05）,or in with partial splenic artery embolization（41.6±4.9） %,（1.7±0.2） and（28.2±4.0） g/L（P<0.05）;the CD8,bilirubin,ALT and prothrombin time were（32.3±4.7） %,（42.7±21.5） μmol/L,（67±35） IU/L and（24.8±3.4）s,significantly higher than in spleen resection group（22.7±3.4） %,（29.2±12.4） μmol/L,（40±26） IU/L and （16.2±3.4）s（P<0.05）,or in with partial splenic artery embolization（23.0±3.6） %,（35.2±13.4） μmol/L,（56±20） IU/L and （16.5±2.9）s（P<0.05）;the incidences of subphrenic infection,pulmonary infection,pulmonary atelectasis,splenic vein inflammation,upper gastrointestinal bleeding were 43.3%,56.7%,26.7%,20.0%,23.3%,significantly higher than in spleen resection group (12.0%,14.0%,6.0%,4.0%,8.0%,P<0.05）,or in with partial splenic artery embolization (10.7%,14.3%,3.6%,3.6%,7.1%,P<0.05）. Conclusion The liver function improves in patients with liver cirrhosis after receiving splenectomy or partial splenic artery embolization.

Key words: Liver cirrhosis, Splenectomy, Partial splenic artery embolization, Liver function