Abstract: Objective To investigate the efficacy and safety of adefovir dipivoxil combined with oxymatrine in the treatment of patients with HBeAg-positive chronic hepatitis B（CHB）. Methods Eighty patients with HBeAg-positive CHB were randomly divided into control group（n=40） and treatment group（n=40）. Patients in control group were treated with ADV,while patients in treatment group were treated with ADV combined with oxymatrine. All patients were treated for 12 months. At 3,6,9 and 12 month,symptoms and signs, serum biochemical parameters,serum HBV DNA levels,serological HBV markers and adverse events were observed. Results At 6,9 and 12 month,serum HBV DNA levels in treatment group were（3.97±1.15）lg copies/ml,（3.38±1.24） lg copies/ml and（3.09±1.19） lg copies/ml,significantly lower than in the controls[（4.61±1.32） lg copies/ml, （4.17±1.12） lg copies/ml and （3.81±1.26） lg copies/ml,respectively,P<0.05];serum alanine aminotransferase （ALT） levels at 3,6 and 9 m were similar between the two groups and were lower than in the pre-treatment levels; serum ALT levels in patients of treatment group at 12 m was（30.1±15.4） U/L,significantly lower than in the controls [（39.9±14.5）U/L,P<0.05];serum HBV DNA loss at 3 m and normalization rates of ALT level at 3 m and 6 m did not differ between the two groups,but the rates of HBV DNA loss in patients in treatment group at 6,9 and 12 m were 55.0%,65.0% and 77.5%,respectively,significantly higher than in the controls[32.5%,42.5% and 57.5%,respectively,P<0.05];normalization rates of ALT level of patients in treatment group at 9 and 12 m were 82.5% and 92.5%,significantly higher than in the controls[60.0% and 75.0%,respectively,P<0.05];negative rates and seroconversion rates of HBeAg for patients in treatment group at 12 m were 47.5% and 42.5%,respectively,significantly higher than in the controls[25.0% and 20.0%,respectively,P<0.05]. Serious adverse reactions did not occur during the treatment process in the two groups. ConclusionsADV combined with oxymatrine in treatment of patients with HBeAg-positive CHB is of good efficacy and safe.

Key words: Chronic hepatitis B, Adefovir dipivoxil, Oxymatrine, HBeAg, Efficacy