JOURNAL OF PRACTICAL HEPATOLOGY ›› 2014, Vol. 17 ›› Issue (2): 206-209.doi: 10.3969/j.issn.1672-5069.2014.02.027

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Pathogenesis effects of transforming growth factor-β1 in hepatitis B virus infection-related liver diseases

Xu Chao, Ma Yong.   

  1. Clinical Liver Diseases Research Center,123rd Hospital,Nanjing Military Command,Bengbu 233000,Anhui Province,China
  • Received:2013-07-18 Online:2014-08-20 Published:2016-04-15

Abstract: Transforming growth factor-β1 (TGF-β1) is a kind of cytokine with broad biological functions. It induces abnormality in cell number and function of immune cells and results in chronic infection of hepatitis B virus (HBV);At the same time,TGF-β1 inhibits HBV replication through different ways;TGF-β1 also promotes liver fibrosis,affects hepatocellular carcinoma in a dual manner,and plays a significant role in the development of liver failure.

Key words: Hepatitis B, Transforming growth factor-β1, Liver fibrosis, Hepatocellular carcinoma, Liver failure