Abstract: Objective To investigate the correlation of serum HBsAg to HBV DNA in patients with HBeAg positive and HBeAg negative chronic hepatitis B. Methods The HBsAg，ALT，AST and HBV DNA were detected in 55 patients with serum HBeAg（+）and 36 with HBeAg（-）chronic hepatitis B. Results The levels of HBV DNA，ALT and AST in HBeAg positive were higher than that in HBeAg negative patients（P<0.05）；The levels of HBsAg in HBeAg positive were lower than that in HBeAg negative patients（P<0.05）；There was a negative in HbeAg positive（r=－0.796，P<0.01），while there was no correlation（r=0.289，P>0.05）in HbeAg negative chronic hepatitis B patients between HBsAg and HBV DNA. Conclusion Detection of serum HbsAg might be useful in patients with chronic hepatitis B.

Key words: Hepatitis B, HBsAg, HBeAg, HBV DNA