Abstract: Objective The aim of this study was to investigate the clinic significance of liver biopsy in asymptomatic chronic hepatitis B virus carriers. Methods 134 individuals with chronic hepatitis B viral carriers received the liver biopsy. Results Liver biopsies showed hepatic necrosis inflammation and fibrosis in 1.49%（2/134）without any change；Among 105 patients who met the HBV DNA≥105copies/ml（or in HBeAg negative patients was≥104copies/ml），there were 80 cases whose liver inflammation≥G2；Between 100 patients with HBeAg（+）and 34 patients with HBeAg（-），there was no significantly statistical difference in their liver inflammation and fibrosis（P=0.308）；the hepatic necrosis inflammation and fibrosis between group with HBV DNA<107copies/ml and those with HBV DNA≥107copies/ml were statistically different（P=0.007，P=0.001）. Conclusions The liver biopsy should be done in chronic hepatitis B carriers in time.

Key words: Hepatitis B carriers, Liver biopsies, Pathology