Abstract: Objective To investigate the clinical and virological characteristics of acute hepatitis B. Methods 37 patients with acute hepatitis B were studied for clinical outcomes and their serum and liver HBV markers were detected. Results On admission，serum alanine aminotransferase in the 37 patients with acute hepatitis B were 1143.64±698.32 U/L，and total billirubin were 83.99±80.44μmol/L；and the normalization of liver function was achieved at 44.41±15.43d；3（8.1%）became chronic carriers，and they were all treated with nucleoside analogues；HBsAg in the 37 patients disappeared at 55.9±44.3d，and HBV DNA at 39.4±25.2d；The results of liver biopsy showed that HBsAg disappeared in 22.6±10.0d with the HBsAg loss rate of 51.4%，and HBcAg disappeared in 29.8±16.5d with the HBcAg loss rate of 73%. Conclusions Most patients with acute hepatitis B recovers with viral clearance. The HBV load at onset maybe predict the outcome of acute hepatitis B.

Key words: Hepatitis B, Clinical features, Viral clearance, Prognosis