Abstract: Objective To evaluate the clinical features，laboratory tests in male patients with primary biliary cirrhosis（PBC）. Methods The clinical data of 19 cases were analyzed retrospectively. Results 17 cases（89%）were middle-elderly aged with mean age of 54±17yr；7 cases（36.7%）were asymptomatic，and 9 cases（47.7%）were decompensated hepatic cirrhosis；The AMA in 13 patients（68.4%）and AMA-M2 in 14（73.7%）were positive；With ursodeoxycholic acid treatment，patients in early stage improved. Conclusion Male patients with PBC have relatively mild clinical symptoms and low autoantibodies，which make the early diagnosis even hard.

Key words: Primary biliary cirrhosis, Male, Anti-mitochondrial antibody