Abstract: Objective To investigate the clinical effect of α interferon combination with Yigan Qingre Jiedu granula on HBeAg positive chronic hepatitis B. Methods Totally 120 patients with HBeAg positive chronic hepatitis B and having signs of internal accumulation of damp-heat type were divided into three groups,40 patients for each group receiving α interferon,α interferon combination with Yigan Qingre Jiedu granula and Yigan Qingre Jiedu granula treatment for six months. Results 3 cases in α interferon group and none in combination group were lost. Combination group was better than herbal group in ALT normalization and herbal group was better than interferon group in symptoms improvement after 6 months’treatment. Rate of HBeAg loss in combination group was better than in the other two groups,with higher HBeAg/Ab seroconversion and HBV DNA undetectable rate but without significant difference. Conclusion α interferon combination with Yigan Qingre Jiedu granula has good therapeutic effect on chronic hepatitis B without obvious adverse effect,but complete response rate needs to be further verification.

Key words: Hepatitis B, α, interferon, Yigan Qingre Jiedu granula, Treatment