Abstract: Objective To explore main molecular mechanism of introhepatic microcirculation obstruction induced by chronic hepatitis B virus. Methods The liver biopsy tissues from patients with chronic hepatitis B,cirrhosis and healthy control were obtained. α-smooth muscle actin（α-SMA）,cyclooxygenase2（COX₂）,COX₁,and angiotensinII in the fibrotic livers and cirrhosis were examined by using immunohistochemistry. Results α-SMA,COX₂,COX₁ and angiotensin II in hepatic sinusoidal wall,little portal venules branch,hepatic arteries branch,central vein,vein wall beneath lobules were positive. They were obviously up-regulated as compared to control. Conclusions Intrahepatic microcirculation changes was found in chronic hepatitis B and cirrhosis.

Key words: Liver cirrhosis, Hepatitis B, Cyclooxygenase, AngiotensinII