TGF-β1、PDGF-BB与慢性乙型肝炎肝纤维化相关性研究

doi:10.3969/j.issn.1672-5069.2010.02.007

Abstract

Abstract: Objective To explore the immunological location and expression of transforming growth factor TGF-β1 and platelet derived growth factor PDGF-BB in different stages on the hepatic fibrosis of chronic hepatitis B,and to discuss the possible effects and correlation in the development of liver fibrosis. Methods A total of 100 cases of chronic hepatitis B were obtained from the liver biopsy. The expression of TGF-β1 and PDGF-BB in fibrotic liver tissue were observed by immune histochemical,and the levels of liver function serum ALT,PTA were simultaneously measured. Results TGF-β1,PDGF-BB were positively related with the stages of hepatic fibrosis,correlation coefficient r for 0.824,0.856（P< 0.05）. There was obvious positive correlation between the expression of TGF-β1 and PDGF-BB,correlation coefficient r for 0.724（P< 0.05）. TGF-β1,PDGF-BB were negatively related with PTA,correlation coefficient r for -0.757,-0.656（P< 0.05）. TGF-β1,PDGF-BB were no related with ALT（P> 0.05）. Conclusion The expression of TGF-β1 and PDGF-BB may play important role in the process of hepatic fibrosis. TGF-β1 and PDGF-BB play a reciprocal promoting role in liver fibrosis.

Key words: Hepatitis B, Hepatic fibrosis, Transforming growth factor β1, Platelet derived growth factor BB

CHEN Yongliang, LI Zhengyan, YAO Chunfu, et al.. Correlation of transforming growth factorβ1 and platelet derived growth factor BB with different stages of chronic hepatits B[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2010, 13(2): 100-103.

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Correlation of transforming growth factorβ1 and platelet derived growth factor BB with different stages of chronic hepatits B

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