Abstract: Objective To study the correlation between HBV PreS1 antigen,HBV M and HBV DNA. Methods PreS1 was detected by ELISA;HBV M by time-resolve dimmuno-fluorescent method;Liver fuction tests by kinetic method and HBV DNA by fluorescent quantitation PCR. Results The positive rates of HBV DNA and PreS1 in patients with HBeAg positive were 97.2% and 92.9%,respectively;That in patients with anti-HBe positive were 39.9% and 37.2%,respectively;and that in patients with HBsAg and anti-HBc positive were 62.7% and 54.2%,respectively. The positive rates of preS1 antigen in patients with chronic hepatitis B of mild,moderate and severe degree were not significantly different. Conclusion The detection of preS1 antigen can reflect the HBV replication and the implication of PreS1 is to be studied.

Key words: Hepatitis B, PreS1 antigen, Viral replication