Abstract: Objective To investigate the correlation of serum ferritin （SF） and liver injuries in patients with chronic hepatitis B and liver cirrhosis after hepatitis B viral infection. Methods SF were detected in 38 patients with chronic hepatitis B,37 with hepatitis B-related liver cirrhosis and in 30 healthy persons,and the relationship between SF and ALT,AST,ALB of liver function,CEA,AFP,Ca125 of tumor markers was analyzed by Spearman rank correlation. Results SF levels in patients with chronic hepatitis B and with liver cirrhosis were（216.79±24.46） μg/l and（220.47±39.38） μg/l,respectively,much higher than in healthy control group[（71.23±4.69） μg/l,P<0.05];There was a significant positive correlation between SF and ALT,AST,GGT,ALP,TBIL,AFP,CA199 and CA50 in patients with chronic hepatitis B,while there was a significant positive correlation between SF and AST,LDH,AFP,CA199,CA724 and CA50 in patients with liver cirrhosis. ConclusionsThere is a significant correlation between SF and AST,AFP and Ca199 in patients with chronic hepatitis B viral infection-related liver disease. SF may be considered as an important reference index in the diagnosis of liver injury. The overload of iron may enhance the hepatic injury. Detection of SF level is useful in diagnosis,prognosis and treatment in patients with liver diseases.

Key words: Chronic hepatitis B, Liver cirrhosis, Serum ferritin