关键词: 非酒精性脂肪肝, 多囊卵巢综合征, 胰岛素抵抗

Abstract: Objective To explore the relationship between nonalcoholic fatty liver disease and polycystic ovary syndrome. Methods A case control study was performed to compare 47 non-pregnant patients with polycystic ovary syndrome with 47 non-pregnant without polycystic ovary syndrome. Clinic anthropometric variables,the prevalence of nonalcoholic fatty liver disease, insulin resistance,abnormal liver function were determined. Results The occurrence of nonalcoholic fatty liver disease,insulin resistance and elevated aminotransferase was 42.6%,68.1% and 34.0%,higher than those in control group respectively（17.0%,10.6%,8.5%,P<0.01）;Compared with patients without nonalcoholic fatty liver disease,patients with nonalcoholic fatty liver disease had significantly increased body mass index,HOMA-IR,follicle-stimulating hormone,luteinizing hormone（P<0.05）,alanine aminotransferase and testosterone（P<0.01）;Patients with polycystic ovary syndrome and nonalcoholic fatty liver disease were younger than the patients only with polycystic ovary syndrome（P<0.01）;Logistic analysis showed that elevated aminotransferase and HOMA-IR had obvious relationship with polycystic ovary syndrome complicated with nonalcoholic fatty liver disease（ALT OR=1.1,P=0.01;HOMA-IR OR=1.6,P=0.01）. Conclusion Nonalcoholic fatty liver disease is common in patients with polycystic ovary syndrome,which suggests an association between those two conditions. Young women with polycystic ovary syndrome should be screened for liver disease early.

Key words: Nonalcoholic fatty liver, Polycystic ovary syndrome, Insulin resistance