关键词: 药物性肝损伤, 病因, 临床特点

Abstract: Objective To analyse causes,clinical features,diagnosis and prognosis of drug-induced liver damage in recent years in order to improve clinical doctors’ understanding of this problem. Methods we scored inpatients with drug-induced liver damage from April 2003 to April 2009 in our hospital according to Maria“clinical diagnosis scales”,and causes of 132 patients among whole patients who scored greater than or equal to 10 were retrospectively analyzed and clinically classified. Result There were more than fifty kinds of drugs from fifteen groups that could induce liver damage. Among these drugs 72.7 percent were Chinese traditional medicine,antitubercular drug,antineoplastic drug and Antibiotics,which were the major medicine that caused liver damage. Incubation period of 5 day to 356 day,the percentage of liver damage happened in fourth week,eighth week,and twelfth week was 61.4 percent,84.9 percent and 91.7 percent respectively.78.8 percent（of the total cases） were hepatocellular injury type,13.6 percent cholestatic type,and 7.6 percent mixed type. There were 27 patients（20.5%） with no clinical symptom and objective sign but abnormal Lab findings. There were 105 patients（79.5%） with clinical symptom such as fatigue（64.4%）,anorexia（53.0%）,and colored urine（41.7%）. Among 104 patients with liver damage,all had their ALT cut down more than 50 percent in 30 days and recovered their liver function in 2 months after discontinuation. Conclusion The main causes of drug-induced liver damage were Chinese traditional medicine,antitubercular drug,antineoplastic drug and Antibiotics. Mostly drug-induced liver damage occurred within 12 weeks,and he longer the drugs are used,the higher the probability of the liver damage occurs.The main damage type were hepatic cellullar damage,and its clinical feature were similar to each acute or chronic liver disease,without specificity,its prognosis were good.

Key words: Drug-induced liver damage, Cause, Clinical feature