关键词: 非酒精性脂肪性肝病, 2型糖尿病, 代偿期进展性慢性肝病, 流行率

Abstract: Objective This study was conducted to investigate the prevalence of non-alcoholic fatty liver diseases (NAFLD) and compensated advanced chronic liver disease (cACLD) in patients with type 2 diabetes mellitus (T2DM). Methods The patients with T2DM from 5 communities in Xingtai City were surveyed between July and September 2021, and an well-designed questionnaires were applied to record the height, body weight, blood pressure, blood glucose and blood lipids, and the liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) were performed by using FibroScan© elastography. The binary Logistic regression analysis was applied to reveal the risk factors of severe NAFLD. Result This study included 946 patients with T2DM in five communities, and the female accounted for 64.5%, much higher than 35.5% in male (P<0.05); the concomitant NAFLD was found in 664 cases (70.2%), including severe in 334 cases (50.3%), moderate in 198 (29.8%) and mild in 132 cases (19.9%); the concomitant cACLD was found in 94 cases (9.9%), and the percentages of cACLD in normal body weight, overweight and obese individuals were 6.1%, 10.5% and 17.6%; the univariate Logistic regression analysis showed that the overweight, obesity, hyperlipidemia, coronary heart disease, and diabetic courses were different between persons with severe NAFLD and those without(P<0.05), and the overweight, obesity, hyperlipidemia, coronary heart disease were different in patients with cACLD and those without (P<0.05); the binary Logistic regression analysis showed that the body mass index was the independent risk factor impacting the concomitant existence of NAFLD in patients with T2DM (P<0.05). Conclusion The prevalence of NAFLD in our series of patients with T2DM is high, and the concomitant cACLD is also reached to 9.9%, which should be appropriately dealt with.

Key words: Non-alcoholic fatty liver diseaseS, Type 2 diabetes mellitus, Compensated advanced chronic liver disease, Prevalence