声触诊组织量化技术测量脾脏剪切波速度评估慢性乙型肝炎纤维化程度的初步研究

doi:10.3969/j.issn.1672-5069.2012.02.011

实用肝脏病杂志 ›› 2012, Vol. 15 ›› Issue (2): 114-116.doi: 10.3969/j.issn.1672-5069.2012.02.011

声触诊组织量化技术测量脾脏剪切波速度评估慢性乙型肝炎纤维化程度的初步研究

张纯林, 童清平, 罗福成, 朱先存, 左鲁生

230031合肥市安徽医科大学解放军临床学院/解放军第105医院超声科（张纯林,童清平,罗福成）;
蚌埠市解放军第123医院特诊科（朱先存,左鲁生）

收稿日期:2012-01-05 出版日期:2012-04-10 发布日期:2017-03-07
通讯作者: 童清平,E-mail：tongqp168@163.com
作者简介:张纯林女,26 岁,硕士研究生。主要从事肝脏疾病超声诊断研究。E-mail:happy2009linlin@126.com

The preliminary study of spleen shear wave velocity measured by virtual touch tissue quantification technique in assessment of liver fibrosis stage in patients with chronic hepatitis B and liver cirrhosis

Zhang Chunlin, Tong Qingping, Luo Fucheng, et al.

Department of Ultrasound,105th Hospital of PLA,Anhui Medical University,Hefei 230031,China

Received:2012-01-05 Online:2012-04-10 Published:2017-03-07

摘要/Abstract

摘要： 目的利用声触诊组织量化技术测量脾脏剪切波速度,探讨脾脏剪切波速度变化对诊断慢性乙型肝炎患者肝纤维化程度的价值。方法利用声触诊组织量化技术对51例慢性乙型肝炎患者、39例肝硬化患者和32例健康人脾脏进行超声检查,测得感兴趣区脾脏剪切波速度,比较三组受检者脾脏剪切波速度值的差异。结果健康人、慢性乙型肝炎和肝硬化患者脾脏剪切波速度值分别为2.0±0.2、2.3±0.4和3.1±0.5,三者间具有显著性差异（P=0.000）,且随着肝纤维化程度的加重,脾脏剪切波速度值明显增高。肝硬化患者脾脏剪切波速度值明显高于慢性乙型肝炎患者,后者又高于健康人。结论声触诊组织量化技术检测脾脏剪切波速度可用于无创评价脾脏硬度信息,并由此推测肝纤维化程度。

关键词: 慢性乙型肝炎, 肝纤维化, 肝硬化, 剪切波速度, 声触诊组织量化技术

Abstract: Objective The virtual touch tissue quantification（VTQ） technique was used to measure spleen shear wave velocity（SWV） for the evaluation of liver fibrosis in patients with chronic hepatitis B. Method 51 patients with chronic hepatitis B,39 with liver cirrhosis and 32 healthy persons were included and their values of SWV in regions of interest of spleen were performed by VTQ technique. Result The values of SWV were 2.0±0.2,2.3±0.4 and 3.1±0.5,respectively in healthy persons,patients with hepatitis B and liver cirrhosis,and they were significantly different among the three groups（P=0.000）;The SWV values increased as the severity of liver fibrosis progressed. Conclusion The VTQ technique could quantitatively reflect the SWV values and noninvasively evaluate the spleen stiffness,which might be an alternative assessment of liver fibrosis in patients with hepatitis B.

Key words: Hepatitis B, Liver fibrosis, Virtual touch tissue quantification technique, Shear wave velocity

张纯林, 童清平, 罗福成, 朱先存, 左鲁生. 声触诊组织量化技术测量脾脏剪切波速度评估慢性乙型肝炎纤维化程度的初步研究[J]. 实用肝脏病杂志, 2012, 15(2): 114-116.

Zhang Chunlin, Tong Qingping, Luo Fucheng, et al.. The preliminary study of spleen shear wave velocity measured by virtual touch tissue quantification technique in assessment of liver fibrosis stage in patients with chronic hepatitis B and liver cirrhosis[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2012, 15(2): 114-116.

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声触诊组织量化技术测量脾脏剪切波速度评估慢性乙型肝炎纤维化程度的初步研究

The preliminary study of spleen shear wave velocity measured by virtual touch tissue quantification technique in assessment of liver fibrosis stage in patients with chronic hepatitis B and liver cirrhosis

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