关键词: 非酒精性脂肪性肝炎, 当飞利肝宁, 卵磷脂, 治疗

Abstract: Objective To observe the clinical efficacy of Dangfei Liganning combined with lecithin for treating patients with non-alcoholic steatohepatitis（NASH）. Methods 116 patients with NASH were randomly divided into three groups. The combination therapy group（n=45）was treated with Dangfei Liganning and lecithin tablets,and the Dangfei Liganning group （n=38）and lecithin group （n=33）were treated with Dangfei Liganning and lecithin tablets orally,respectively. The regimen lasted for three months.Before and after treatment,clinical data including main symptoms,hepatic function parameters,blood cholesterol and fatty liver image under B ultrasound in the three groups were monitored respectively. Results The rates of symptoms alleviation such as fatigue,anorexia,abdominal discomfort in the combination therapy group were higher than in the lecithin group（x²=3.94,x²=10.63,x²=8.54,P<0.05 or P<0.01）. Fatigue improvement was better in the Dangfei Liganning group than in the lecithin group（x²=3.97 or P<0.05）;The levels of AST and ALT were declined obviously in the combination therapy group and Dangfei Liganning group than in the lecithin group after treatment（P<0.05 or P<0.01）. AST,ALT,TG,TC were also lower in the combination therapy group than in the Dangfei Liganning group （P<0.05 or P<0.01）;Fatty liver under B ultrasound in the combination therapy group and lecithin group were obviously improved after treatment（P<0.05 or P<0.01）; Some patients had abdominal distension,nausea,anorexia and other gastrointestinal reactions after taking Dangfei Liganning. Conclusion Dangfei Liganning combined with lecithin has good clinical efficacy and security for the treatment of patients with NASH.

Key words: Non-alcoholic steatohepatitis, Dangfei Liganning, Lecithin, Therapy