超声引导下三种不同微创方法治疗单纯性肝囊肿患者疗效比较研究*

doi:10.3969/j.issn.1672-5069.2026.05.028

摘要/Abstract

摘要： 目的分析比较三种微创方法治疗单纯性肝囊肿(SHC)患者的疗效。方法 2021年3月～2024年3月我院诊治的97例SHC患者,被分为A组(n=29)、B组(n=33)和C组(n=35),分别采取在超声引导下无水乙醇注射、射频消融(RFA)或聚桂醇泡沫注射硬化治疗。采用全自动免疫分析仪检测血清高尔基体蛋白73(GP73)、蛋白质二硫键异构酶A3(PDIA3)和几丁质酶3样蛋白1(CHI3L1)水平。结果治疗后,C组血清GP73、PDIA3和CHI3L1水平分别为(24.4±3.6)pg/L、(67.7±5.2)ng/mL和(46.4±5.8)ng/L,均显著低于B组【分别为(31.4±4.3)pg/L、(82.7±5.4)ng/mL和(61.8±6.4)ng/L,P<0.05】或A组【分别为(34.2±4.4)pg/L、(89.8±6.7)ng/mL和(66.3±6.8)ng/L,P<0.05】;在术后3个月复查,C组囊肿消失率和总有效率分别为85.7%和97.1%,均显著高于A组的58.6%和86.2%(P<0.05),B组分别为75.8%和93.9%;在术后6个月复查,C组囊肿复发率为5.7%,显著低于A组的27.6%(P<0.05),B组为15.2%; A组术后醉酒样反应发生率为34.5%,而B组和C组不良反应发生率显著减低(P<0.05)。结论我们推荐在超声引导下聚桂醇注射硬化治疗SHC患者,因为疗效好,且安全性更高。

关键词: 单纯性肝囊肿, 超声引导, 聚桂醇, 无水乙醇, 射频消融, 治疗

Abstract: Objective This study was aimed to compare the efficacy of three different minimally invasive treatments for patients with simple hepatic cysts(SHC). Methods 97 patients with SHC were admitted to our hospital between March 2021 and March 2024, and were divided into group A(n=29), B(n=33) and C(n=35), receiving intra-cystic absolute ethanol sclerotherapy, radiofrequency ablation (RFA) or polidocanol foam sclerotherapy all under ultrasound (US) guidance. Serum Golgi protein 73 (GP73), protein disulfide isomerase A3 (PDIA3) and chitinase-3-like protein 1 (CHI3L1) levels were measured by using an automatic immunoassay analyzer. Results After treatment, serum GP73, PDIA3 and CHI3L1 levels in group C were (24.4±3.6)pg/L, (67.7±5.2)ng/mL and (46.4±5.8)ng/L, all significantly lower than [(31.4±4.3)pg/L, (82.7±5.4)ng/mL and (61.8±6.4)ng/L, respectively, P<0.05] in group B or [(34.2±4.4)pg/L, (89.8±6.7)ng/mL and (66.3±6.8)ng/L, respectively, P<0.05] in group A; by end of three-month after treatment, cyst disappearance and total effectiveness rates in group C were 85.7% and 97.1%, both much higher than 58.6% and 86.2%(P<0.05) in group A, and they were 75.8% and 93.9% in group B; by end of six-month after treatment, cyst relapse in group C was 5.7%, much lower than 27.6%(P<0.05) in group A, and that was 15.2% in group B; incidence of intoxication-like reaction after alcohol injection in group A was 34.5%, while adverse effects in group B and C were much lower than in group A(P<0.05). Conclusion We strongly recommend polidocanol sclerotherapy under US guidance in dealing with patients with SHC, which could provide a best therapeutic efficacy, with higher safety.

Key words: Simple hepatic cyst, Ultrasound-guidance, Polidocanol, Absolute ethanol, Radiofrequency ablation, Therapy

梁蓁, 李瑶, 王莹. 超声引导下三种不同微创方法治疗单纯性肝囊肿患者疗效比较研究^*[J]. 实用肝脏病杂志, 2026, 29(5): 749-752.

Liang Zhen, Li Yao, Wang Ying. Efficacy comparison of three different minimally invasive treatments for patients with simple hepatic cysts[J]. Journal of Practical Hepatology, 2026, 29(5): 749-752.

参考文献

[1] Ji DA, Chai J P, Jia S L, et al. Historical changes in surgical strategy and complication management for hepatic cystic echinococcosis. World J Gastrointest Surg, 2023, 15(8): 1591.
[2] Mihetiu A, Bratu D G, Sandu A, et al. Specialized laparoscopic devices in the treatment of hydatic hepatic cysts: a retrospective analysis and review of the literature. Cureus, 2024, 16(3):219-223.
[3] 李玮健,刘昕,舒红艳. 超声引导下聚桂醇与无水乙醇注射硬化治疗肝囊肿患者疗效比较研究. 实用肝脏病杂志,2024,27(3):450-453.
[4] Shen R, Cheng R, Zhou H, et al. Ultrasonography-guided radiofrequency ablation combined with lauromacrogol sclerotherapy for mixed thyroid nodules. Am J Transl Res, 2021, 13(5): 5035.
[5] Wang S, Yin M, Xia Z. Efficacy and preliminary dose studies of ultrasound-guided sclerotherapy with lauromacrogol for the treatment of implanted hepatic tumors in rabbits. J Gastrointest Oncol, 2023, 14(1): 265.
[6] Dai Y, Zhang X, Xu Y, et al. The protective effects of cinnamyl alcohol against hepatic steatosis, oxidative and inflammatory stress in nonalcoholic fatty liver disease induced by childhood obesity. Immunol Investig, 2023, 52(8): 1008-1022.
[7] Marrero J A, Ahn J, Reddy R K, et al. ACG clinical guideline: the diagnosis and management of focal liver lesions. Am J Gastroenterol, 2014, 109(9): 1328-1347.
[8] Zhang Z Y, Wang Z M, Huang Y. Polycystic liver disease: classification, diagnosis, treatment process, and clinical management. World J Hepatol, 2020, 12(3): 72.
[9] Ugli N Z N, Servetovna A A, Ogli G S O, et al. Diagnosis and surgical treatment of echinococcal cyst of the liver. Res Focus, 2024, 3(4): 76-81.
[10] Luo S, Feng P, Li Y, et al. Efficacy and safety of ultrasound-guided percutaneous aspiration-sclerotherapy with anhydrous ethanol for adult simple renal cyst: a multicenter, prospective, randomized controlled trial. Quant Imaging Med Surg, 2025, 15(7): 6436.
[11] 贾永利,王鹏川,郭伟,等. 超声引导下穿刺注射聚桂醇或无水乙醇治疗肝囊肿患者疗效研究. 实用肝脏病杂志,2024,27(1):125-128.
[12] Karpova R V, Petrenko D A, Saribekian A G, et al. Microwave ablation of hepatic cyst: A case report. Ann Med Surg, 2021, 61: 13-15.
[13] Yue W, Dong G, Qing Y, et al. Safety and efficacy of ultrasound-guided radiofrequency ablation in the treatment of gallbladder polyps.Acad Radiol, 2024, 31(8): 3157-3164.
[14] 王苓入,苏虹,郝晓炜,等. 超声引导下PTGD联合聚桂醇硬化治疗SHC患者疗效研究. 实用肝脏病杂志,2024,27(3):454-457.
[15] Zou L, Li C, Chen X, et al. The anti-inflammatory effects of cinnamyl alcohol on sepsis-induced mice via the NLRP3 inflammasome pathway. Ann Transl Med, 2022, 10(2).
[16] Eso Y, Shimizu H, Takai A, et al. Ultrasound-guided polidocanol foam sclerotherapy for symptomatic giant hepatic cyst: A single-center experienc. Hepatol Res, 2022, 52(6): 557-565.
[17] Xu Z, Yang D, Xue Y, et al. Clinical significance of PDIA3 expression in hepatocellular carcinoma and its effect on the expression of IL6 and IL17. Chin J Endocr Surg, 2022: 352-355.
[18] Peng Y, Zeng Q, Wan L, et al. GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity. Nat Commun, 2021, 12(1): 7004.
[19] 张琼,陈士颖,夏维. 超声引导下无水乙醇与聚桂醇硬化治疗单纯性肝囊肿患者效果比较研究. 实用肝脏病杂志,2023,26(3):428-431.
[20] 屈珍,郭巧玲,肖洒,等. 超声引导下穿刺抽液联合聚桂醇或无水乙醇硬化治疗单纯性肝囊肿患者临床疗效比较研究. 实用肝脏病杂志,2025,28(4):613-616.

超声引导下三种不同微创方法治疗单纯性肝囊肿患者疗效比较研究^*

Efficacy comparison of three different minimally invasive treatments for patients with simple hepatic cysts

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	高原, 张爱兰, 林丽泉, 程小桂. 应用富马酸丙酚替诺福韦和富马酸替诺福韦二吡呋酯治疗慢性乙型肝炎患者疗效分析^*[J]. 实用肝脏病杂志, 2026, 29(5): 661-664.
[2]	李甜甜, 吴岩. GLP-1受体激动剂治疗2型糖尿病合并非酒精性脂肪性肝炎患者临床疗效研究^*[J]. 实用肝脏病杂志, 2026, 29(5): 673-676.
[3]	刘德军, 刘婧, 袁翊. 自身免疫性肝炎患者血清AAPR、LECT2和IL-21水平变化及其临床意义探讨^*[J]. 实用肝脏病杂志, 2026, 29(5): 677-680.
[4]	赵先群, 闫斌斌, 李德洋, 田春阳, 张向东. 原发性胆汁性胆管炎患者临床特征、自身抗体特点和预后分析^*[J]. 实用肝脏病杂志, 2026, 29(5): 685-688.
[5]	陈丽虹, 刘银辉, 高梅芳, 李品娣, 吴伟新, 张玮, 李洪昌. 肝病专用型肠内营养制剂治疗失代偿期乙型肝炎肝硬化患者临床疗效研究^*[J]. 实用肝脏病杂志, 2026, 29(5): 705-708.
[6]	茹秀峰, 秦琳, 董小平, 李振平, 何锦来, 胡永辉. 脾动脉高选择性插管部分脾栓塞术治疗肝炎肝硬化并发脾功能亢进症患者临床疗效研究^*[J]. 实用肝脏病杂志, 2026, 29(5): 713-716.
[7]	冯丹丹, 刘子涵, 郝苗, 苟国娥, 党双锁. TACE联合仑伐替尼和卡瑞利珠单抗治疗中晚期原发性肝癌患者临床疗效和安全性研究^*[J]. 实用肝脏病杂志, 2026, 29(5): 721-724.
[8]	朱贺, 李瑶姬, 王锐, 沈志纲. 信迪利单抗联合仑伐替尼治疗中晚期原发性肝癌患者疗效研究^*[J]. 实用肝脏病杂志, 2026, 29(5): 729-732.
[9]	张莉, 杨均铖, 王佳, 杨国栋, 毛欢, 罗云蔓. 增强CT扫描评估TACE术治疗原发性肝癌患者效果研究^*[J]. 实用肝脏病杂志, 2026, 29(5): 733-736.
[10]	吴红, 沈兰超, 姜正伟, 吕春, 蒋培莉. C-TACE与D-TACE治疗原发性肝癌患者疗效与安全性比较研究^*[J]. 实用肝脏病杂志, 2026, 29(5): 737-740.
[11]	刘燕, 周祥, 钟玲. 超声引导下经皮穿刺置管引流治疗化脓性肝脓肿患者疗效研究^*[J]. 实用肝脏病杂志, 2026, 29(5): 753-756.
[12]	祝平, 朱佳, 李晓飞, 魏源, 卢西雅. 内镜下鼻胆管引流联合ERCP/EST治疗胆总管结石合并中重度急性胆管炎患者疗效研究^*[J]. 实用肝脏病杂志, 2026, 29(5): 773-776.
[13]	韩博强, 杨林, 张成, 周党军, 赵宝国, 李文翰. 急性梗阻性化脓性胆管炎患者病原菌分布及ERCP治疗疗效研究^*[J]. 实用肝脏病杂志, 2026, 29(5): 777-780.
[14]	李文静, 汪奕慧, 马韩婷, 孙杰. 内镜逆行胰胆管造影和经皮肝穿刺胆道引流姑息性治疗肝门部胆管癌患者临床疗效研究^*[J]. 实用肝脏病杂志, 2026, 29(5): 789-792.
[15]	杨国慧, 鲍诗平. 慢性乙型肝炎患者鼻内镜术后医用交联透明质酸钠凝胶填塞效果研究[J]. 实用肝脏病杂志, 2026, 29(4): 501-504.